Kelly McKeon added a double-double with 14 points and 10 rebounds for the Mules (23-3) to lead her team to the championship game against the winner of Franklin & Marshall and Johns Hopkins.
Ashley Lyles (Laurel, Md./St. Vincent Pallotti) led the Green Terror (15-12) with a double-double of her own, recording 16 points and 11 rebounds.
Holding a 4-2 lead with 16:55 to play in the opening half, Muhlenberg tallied the next 14 points to open up a 16-2 lead with 12:17 showing. Cook keyed the run with eight points.
A 7-0 McDaniel burst pulled the visitors within seven but the Mules countered with another 14-5 run to stretch the advantage to 30-14 with 2:44 remaining in the opening half.
Muhlenberg held a 34-20 lead at the intermission and stretched the lead to 20 for the first time at 52-32 with 13:39 to play.
Six straight Mule points between the 8:06 mark and the 5:42 mark swelled the lead to its largest at 64-38 before the Green Terror closed the game scoring 13 of the final 16.