The Green Terror (4-3) got a goal in each half to earn its first shutout of the season a day after being shutout.
Chelsea Baker stopped 22 of the 33 shots she faced for the Marlins (1-5), who were outshot 33-8 on the day.
With 9:45 remaining in the first half, Pickard got an unassisted goal to stake her team to a 1-0 lead at the intermission.
Just 2:05 into the second half, Brooke Dixon (Clayton, Del./Smyrna) converted a penalty stroke for the game’s final goal.
Erika Wawzyanick (Wantage, N.J./High Point Regional) made four saves for McDaniel, which was awarded 14 penalty corners to Virginia Wesleyan’s four.
The Green Terror returns to action at home against Elizabethtown on Wednesday. Game time is 4:30 p.m.
Score by Period 1 2 - F
McDaniel (4-3) 1 1 - 2
Virginia Wesleyan (1-5) 0 0 - 0
M – Mandy Pickard, 25:15
M – Brooke Dixon (penalty stroke), 37:05
Shots: M 33, V 8. Penalty Corners: M 14, V 4. Saves: M 4 (Erika Wawzyanick); V 22 (Chelsea Baker).